Anal cancer and HPV: what every adult needs to know

Anal cancer and HPV: what every adult needs to know

Anal cancer is uncommon, and it grows less rare every year. The American Cancer Society estimates about 11,270 new cases in the United States in 2026 and about 1,700 deaths. The disease begins in the squamous cells that line the anus, and most cases trace back to one virus that millions of adults already carry without knowing it.

A small cancer with a rising count

Anal cancer sits far down the list of common cancers, yet its trend line tells a sharper story. National data from the NCI Surveillance, Epidemiology, and End Results program show incidence climbing about 2.2% each year from 2012 to 2021. Deaths rose about 5.1% each year from 2013 to 2022. The lifetime risk for any single person stays low, near 0.2%. The direction of that curve is what public health teams watch, because a rare cancer that keeps rising eventually reaches people who never thought it applied to them.

Women carry more of this burden than men. The 2026 estimate counts 7,700 cases in women and 3,570 in men. Older adults are diagnosed most often, and rates among older women have moved up steadily over the past decade. Many older Latina women fall inside that rising group, which gives the topic real weight for families across Georgia.

Why HPV is the center of the story

The human papillomavirus drives the great majority of these cancers. HPV is a common infection, and most sexually active people encounter it at some point in their lives. The Centers for Disease Control and Prevention reports that about 91% of anal cancers are caused by HPV, which works out to roughly 7,600 of the 8,348 cases diagnosed in a typical year. The American Cancer Society names HPV infection as the most important risk factor for the disease, and HPV-16 accounts for the largest share of these cancers.

HPV causes six cancers in all: cervical, vaginal, vulvar, penile, anal, and oropharyngeal, the last covering the back of the throat, the base of the tongue, and the tonsils. One virus, one set of prevention tools, six places in the body. That overlap is why a single vaccine can lower the risk of several cancers at once.

Risk, and a word about stigma

Some adults face higher odds than others. People living with HIV and others with a weakened immune system are far more likely to develop anal cancer. Smoking raises the risk, and quitting brings it down. A previous HPV-related cancer of the cervix, vulva, or vagina also raises it.

Anal cancer carries a layer of embarrassment that keeps people from asking questions, and that silence has a cost. A virus that nearly everyone encounters causes this disease. Talking with a clinician about prevention belongs in the same category as any other part of routine adult health.

Vaccination is the strongest prevention

The HPV vaccine protects against HPV-16 and HPV-18, the types behind most HPV cancers. It works best when given before any exposure to the virus, which is why pediatricians start the series at a young age. Adults who missed it still have a path forward.

The CDC recommends catch-up vaccination for everyone through age 26. Many adults between 18 and 26 never finished the series, or never started it as teenagers, and they can complete it now. For adults 27 through 45, the decision is made together with a clinician who weighs personal history and risk. Knowing your own vaccination status is the first step, and a clinic can help you pull your records if you are not sure.

Screening, and what the evidence shows

No national screening program covers anal cancer in the general population. The U.S. Preventive Services Task Force lists the topic as inactive, which means it has issued no recommendation for routine screening.

The picture is shifting for higher-risk groups. The federally funded ANCHOR trial found that treating anal precancer cut progression to cancer by 57% among people 35 and older living with HIV. The finding was strong enough that the National Cancer Institute ended the study early in 2022. Adults at higher risk can ask a clinician whether an anal Pap test or a high-resolution anoscopy fits their situation. An anal Pap test collects cells much as a cervical Pap does, and a high-resolution anoscopy lets a clinician examine the lining closely when a test comes back abnormal.

Where to ask in Atlanta

Hispanic and Latino adults across metro Atlanta can raise these questions at a regular checkup or a community clinic. Grady Health System, the Georgia Department of Public Health, and Emory HPV Cancer Free Georgia support HPV vaccination and can guide you toward the right care. HHCGA's bilingual navigators help families find a provider, read their vaccination records, and book the visit.

The strongest move is the simplest one. Ask whether you finished the HPV series, and if not, find out when you can start. One vaccine, six cancers, and a question that takes a minute to raise.

3.

Common questions

Who should get the HPV vaccine as an adult?

The CDC recommends catch-up HPV vaccination for everyone through age 26. Adults 18 to 26 who never finished the series can complete it now. Adults 27 through 45 can decide with a clinician based on personal history and risk.

How much anal cancer is linked to HPV?

The CDC reports that about 91% of anal cancers are caused by HPV, roughly 7,600 of the 8,348 cases diagnosed in a typical year. The American Cancer Society names HPV as the most important risk factor for the disease.

Is there a routine screening test for anal cancer?

No national screening program covers the general population, and the U.S. Preventive Services Task Force lists the topic as inactive. People at higher risk, including those living with HIV, can ask a clinician whether an anal Pap test or high-resolution anoscopy is right for them. The ANCHOR trial found that treating anal precancer cut progression to cancer by 57% in people 35 and older living with HIV.

Community partners

Georgia Department of Public Health

Emory HPV Cancer Free Georgia

HPV Vaccination Roundtable of the Southeast (St. Jude)

Grady Health System

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